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This methylation profile is currently acquired in the MBL stage3 and continues to be somewhat stable as time passes. Nevertheless, some CLL have intratumor variability in specific locations, which can change the expression of various genes and facilitate tumor evolution.seventy one Of Take note, this variability is greater in U-CLL than in M-CLL which is affiliated with escalating quantity of subclones.seven,71
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mutations and complex kar yotype. It follows a linear evolution from the CLL clone from the recurrent acquisition of CDKN2A
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translocations or amplifications on top of the genomic alterations by now present in the original CLL, but absence the prevalent mutations observed in primary DLBCL indicating which they may well correspond to a distinct Organic classification.